Helicobacter Pylori: Pathogenesis, Symptoms and Incubation

Helicobacter Pylori: Pathogenesis, Symptoms and Incubation Helicobacter pylori (H. pylori) are a type of intestinal bacteria (spiral-shaped gram-negative) that cause the majority of ulcers in the stomach and duodenum. They thrive in highly acidic environments and have a unique way of adapting to the harsh environment of the stomach. H. pylori have been classified as low-potential carcinogens (cancer-causing substances) by the World Health Organization. The Life Cycle (Pathogenesis) of Helicobacter pylori H. pylori are able to survive in stomach acid because they produce enzymes (special proteins) that neutralize the acid. This mechanism allows H. pylori bacteria to enter the stomach and make their way to the safe area the protective mucous lining of the stomach wall. When the bacterium is in the mucous lining of the stomach, the bodys natural defenses cannot reach it. The immune system will respond to an H. pylori infection but will not be able to kill the bacteria since they are hidden in the stomach lining. The immune system will keep sending infection fighters to the infection site and H. pylori will feed on the nutrients provided by the body, allowing them (the bacteria) to survive in the stomach environment. H. pylori weaken the protective mucous coating of the stomach and duodenum, allowing the stomach acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining, causing gastritis (stomach inflammation) and perhaps the formation of an ulcer within a few days of the initial infection. Ironically, it may not be the H. pylori bacteria, but the inflammation response to the bacteria, that causes the ulcer to form. The series of steps the pathogenic mechanisms that H. pylori go through when establishing themselves in the stomach are as follows: Attachment The H. pylori bacteria must enter the stomach and attach themselves to the lining of the stomach to establish an environment in which to grow. Toxin production H. pylori produce poisonous substances to increase the secretion of water and electrolytes in the stomach and cause cell death in the cells of the stomach lining. This will help the bacteria take over the stomach environment and will lessen the competition for required nutrients. Cell invasion The bacteria will enter the stomach lining cells for protection and will then kill the cells they are in (their host cells) so that they can move on to invade more stomach-lining cells. This process will continue, thus creating tissue damage. This tissue damage will become the ulcer formation in the stomach. Loss of microvilli/villi The substances released into the host cell during the Cell Invasion step cause a change in the stomach-lining cells. This change results in fewer calories getting absorbed by the stomach. The consequence? The body will get fewer nutrients from the food eaten at every meal. Ulcers occur when there is a break down in the mucous layer lining the stomach, allowing the gastric (stomach) acid and digestive enzymes to attack and aggravate the actual stomach muscle. Helicobacter pylori contribute to this breakdown by  living in this layer and increasing the chances of it breaking down. Stress and diet may irritate an ulcer, but do not cause it. Symptoms and incubation time of an H. pylori infection Getting an H. pylori infection is nothing like catching a common cold in that immediate consequences of an infection are rarely seen. In fact, it is possible to go many years without noticeable symptoms. When symptoms do occur, abdominal discomfort is the most common. This discomfort is usually a dull, gnawing ache that comes and goes for several days or weeks. It usually occurs two to three hours after a meal or in the middle of the night (when the stomach is empty) and is relieved by eating, drinking milk or taking antacid medications. Other symptoms include: heartburn, increased burping, weight loss, bloating and burping, and less common symptoms include: poor appetite, nausea and vomiting. If you suspect that you have an ulcer and experience any of the following symptoms, a doctor should be called right away. Sharp, sudden, persistent stomach pain Bloody or black stools Bloody vomit or vomit that looks like coffee grounds The above symptoms could be signs of a serious problem, such as: Perforation when the ulcer burrows through the stomach or duodenal wall. Bleeding when acid or the ulcer breaks a blood vessel. Obstruction when the ulcer blocks the path of food trying to leave the stomach. Epidemiology Infection with H. pylori occurs worldwide, but the prevalence varies greatly among countries and among population groups within the same country. The overall prevalence of H. pylori infection is strongly correlated with socioeconomic conditions. The prevalence among middle-aged adults is over 80 percent in many developing countries, as compared with 20 to 50 percent in industrialized countries. Prevalence of infection is higher in developing countries than that of developed nations. In developed countries,although overall prevalance of infection in young children is Helicobacter pylori infection is common in the Indian subcontinent. Exposure occurs in childhood and approximately 80% of adults have been infected at some time. Sero-surveys indicate a seroprevalence of 22%-57% in children under the age of five, increasing to 80%-90% by the age of 20, and remaining constant thereafter. There is now evidence from epidemiological studies that H pylori carriers have a significantly greater risk for the development of gastric cancer. Results from three prospective epidemiological studies10-12 estimate that H pylori carriers have a 2.8- to 6.0-fold increased risk of gastric cancer developing over mean follow-up periods of 6 to 16 years when compared with their H pylori-negative counterparts. The overall mean risk was calculated to be 3.8.13 This odds ratio increased to 8.7 in those who were diagnosed 15 years or more after testing positive for H pylori. H. pylori infection- treatment Ulcers caused by H. pylori can usually be cured with a one or two-week course of antibiotics. Treatment usually involves a combination of antibiotics, acid suppressors, and stomach protectors. Acid suppression by the H2 blocker or proton pump inhibitor in conjunction with the antibiotics helps alleviate ulcer-related symptoms, helps heal gastric mucosal inflammation and may enhance the effectiveness of the antibiotics against H. pylori at the gastric mucosal surface. The use of only one medication to treat H. pylori is not recommended. At this time, the most proven effective treatment is a two-week course of treatment called triple therapy. It involves taking two antibiotics to kill the bacteria and either an acid suppressor or stomach-lining protector to protect the stomach lining. Two-week triple therapy reduces ulcer symptoms, kills the bacteria, and prevents ulcer recurrence in more than 90 percent of patients, but, unfortunately, patients may find triple therapy complicated beca use it involves taking as many as twenty pills a day. The antibiotics used in triple therapy may cause mild side effects such as: nausea, vomiting, diarrhea, dark stools, metallic taste in the mouth, dizziness, headache, and yeast infections in women. Marketted formulation available in India for H.pylori infection Brand name Chemicals Company HELIBACT combi-pack Omeprazole 20 mg,amoxycillin 750mg,tinidazole 500mg. RPG LS HELIKIT kit Omeprazole(1cap) 20 mg,amoxycillin(1 tab) 750mg,tinidazole(1 tab) 500mg. Zydus cadila L-COT kit 1 cap Omeprazole 20mg,1 tab Clarithromycin 250mg,tinidazole 500mg LUPIN PYLOKIT kit 2 caps of lansoprazole 30mg,2 tabs of tinidazole 500mg,2 tabs of clarithromycin 250mg CIPLA ZOVANTA kit 2 tabs of amoxicillin 750mg,2 tabs of tinidazole 500mg,2 tabs of pantoprazole 40mg Dr.Reddys

Analysis of Twain’s on the Decay of the Art of Lying

Critical Analysis On the Decay of the Art of Lying by Mark Twain â€Å"Lying is universal – we all do it. † In the essay, the author believes that all men lie because we must lie. There are many instances wherein men were prompted to lie at some point of their lives for the benefit of others. According to him, it’s better to give a good lie than a destructive truth. Lying for other’s advantage was given precedence than telling the truth at all times no matter how it hurts. Unfortunately, lying is easily covered with different alibis and given little thought of how destructive it might become on the long run. Twain considers lying as a noble art. It is the fourth grace and an eternal virtue. â€Å"Judicious lying is what the world needs,† he said. He’d sometimes think that it’s better not to lie if the lie will be destructive to others. For him, a habitual truth-teller [someone who speaks truthfully at all times] doesn’t exist and had never existed. The author gives us a simple look on how lying had become the fad of his generation. Even in the tiniest of things, people tend to lie. It goes to show that many are pretentious and still is today. However, the author overlooks one thing. True – a lie for the good of another might be reasonable – but lying will always be lying. Truth hurts indeed but a lie hurts even more when unveiled. As far as God is concerned, liars go to hell. A small lie can lead people to the lake of fire. Of course, God forgives sins. He forgives lying, too, so long as the person will repent from it. Avoiding lies might be hard to do with all the deception and temptation going on around but it’s not impossible. Fearing to tell the truth means that you’re afraid of what will happen to you. In order to protect one’s self from being punished or from hurting others, lying becomes the scapegoat. Eventually, it develops into a habit and you become a ‘master’ at it. For Twain, he is still a newbie in this game. He would like for this art to be cultivated in the forms of charitable and unselfish lying. Again, lying is always and has always been a manifestation of selfishness. Lastly, uttering lies won’t disappear in the years ahead but it’s elevation as a virtue might need some thinking. It is an agonizing fact that some think the same way as Twain does. The difference is that he (Twain) was able to voice out his opinions in a very artistic way through his writing while other people don’t care that much. This essay is an eye opener for all the people in this world about the art of lying. This form of art encompasses race, gender and culture. Different punishments await the liar but that never abolished it altogether. As long as people continue to let lies surround them, this art won’t be decaying soon. â€Å"For the sin of their mouth and the words of their lips let them even be taken in their pride: and for cursing and lying which they speak. † Psalm 59:12 KJV

The Philosophical Study of Morality

IntroductionOur behavior reflects on our personalities. Morality speaks of a system of action in regards to standards of right and wrong behavior. Morality describes the principle that presides our behavior. Without this principle, societies cannot survive for so long. In today's Society, morality is frequently thought of as inseparability to a particular religious point of view. Moral describes the principle that controls our behavior. In everyday living, we are witnessing such crimes of killings. But we, the citizen of this country are looking for this as the usual that happens every day. And we're not looking for the reason of those people who kill or commit crimes. We don't really know what's the reason behind it and if there's no reason, but we judge them for no reason. What is moral being instead? Judging others or committing crimes? They are saying that we are religious country and they said that the person here is also religious, but how those people commit crimes if they are really religious? Does being religious can be a Moral person? Or Does Moral principle helps us being a Religious person? The word carries the concepts of:Moral Standards with regards to behaviour;Moral responsibility, referring to our conscience; andA moral identity or one who is capable of right or wrong action. It explored the action of morality and examines how people should live their lives in relation to others.Background of the StudyAccording to www.allaboutphilosophy Morality as it relates to our behavior is important on three levels. Renowned thinker, scholar and author C.S Lewis defines them as:to ensure fair play and harmony between individuals,to help make us good people in order to have a good society,to keep us in a good relationship with the power that created us. Based on this definition, it's clear that our belief is disapproving to our moral behavior.On point 1, Professor Lewis says most reasonable people agree. By point 2, however, we begin to see problems occurring. Consider the popular philosophy â€Å"I'm not hurting anyone but myself†, frequently used to excused bad persona l choices. How can we be the good people we need to be if we persist in making these choices? Bad personal choices do hurt others. Point 3 is where most disagreement surfaces.Exposition of the problemThere are different definition of morality, first is the moral standards it explains the right and wrong behavior of a human person the second is the moral responsibility it explains the conscience or the guilt of a human person, and thirdly is the moral identity it explains that each Human have their own decision and capable of right and wrong action or doing. Morality speaks about ethnics, principles, virtue, and goodness. Morality is very complicated to explain yet; morality always depicts our behavior it controls and limits us.Is Morality Objective?According to philosophynow.org/issues/115/Is_Morality_Objective Great moral philosopher differs about the character of morality. Immanuel Kant's influential duty-based theory of ethnics maintains that truth-telling is universally binding on all of beings. In a pristine world a crystallized moral ideals, perhaps morality could be objective and universally binding on all people. However, we live in a world of moral flux, impermanence and flexibility. And it is because of this that morality is not nor could ever be objective. -Albert Filice, Scottsdale, AZ Morality is objective. That is, moral claims are true or false about aspects of human interaction that involve the ideas of rights and obligations. Further, the fundamental moral maxims apply universally, and reasonable people can agree on their truth. -John Talley, Rutherford on, NC. Is there any way to know the difference between right and wrong? Does religion have anything left to offer? From time to time we hear that the established churches are in bafflement that too often their leaders have nothing to say that's applied and helpful where does the truth on these signify lie? The relationship between religion and morality has long been hotly debated. Does religion make us more moral? Is it Essential for morality? Does moral partiality emerge independently of religious intuitions?Philosophical ResponseA recent report in psychology today concluded â€Å"the most significant predictor of a person's moral behavior may be religious commitment. People who consider themselves very religious were least likely to report deceiving their friends having extramarital affairs, cheating on their â€Å"programmed† in each of us. This is in keeping with the writings of Paul Apostle, who points out that even those who do not believe in God frequently obey God's as given in the ten commandments, â€Å"for when gentiles, who do not have the law by nature do not have, these although not having law, are a law to themselves, who show the work of the law written in their hearts, their conscience also bearing witness and between themselves their thoughts accusing or else excusing themselves† (Romans 2:14-15; NKJV). Again those who do not believe in God are left with the only possible conclusion they can come to that our decision are based solely on our need to survive, what we call our conscience based on learned behavior, rather than part of a Devine design. Many scientific researchers have failed to disintegrate â€Å"religion† and â€Å"morality† into theoretically grounded elements; have adopted illiberal conceptions of key concepts in particular, sanitized conceptions of â€Å"prosocial† behaviour; and have neglected to consider the complex interplay between cognition and culture. They argue that to make progress, the categories â€Å"religion† and â€Å"morality† must be fractionated into a set of biologically and psychologically cogent traits, revealing the cognitive foundations that acclimate and obligate relevant cultural variants. Being religious doesn't make us Moral person because we, in ourselves know if we commit mistake and if we are doing good deeds. Yes, doing right seems that you are having with the lord but doesn't mean that we are moral. Being a moral is seeing in our action not only to our faith by our god. Every one of us have different definition of god, so that being a moral person is not depending on being a religious one. The question of whether or not morality claims religion is both topical and ancient. In the Euthyphro, Socrates famously asked whether goodness is loved by the god because it is good, or whether goodness is good because it is loved by the god. Although he favoured the former proposal, many others have argued that morality is dictated by, and indeed inconceivable without God: â€Å"If god does not exist, everything is permitted†. (Dostoevsky, 1880, 1990) According to Aristotle, there are two meaning of good. There is good absolutely and there is good for somebody. The first one is he/she was doing it because it is good. And the other one is doing it for others, in short doing it for a purpose or reason. In that based, we can judge the others by doing wrong because we are all people, maybe it is right for them because it was for their love ones.ConclusionMoral philosophy is the branch of philosophy that contemplates what is right and wrong. It explores the nature of morality and examines how people should live their lives in relation to others. Almost every day, the Philippine media are always flooded with stories of horror about people getting killed. Killing in itself is very dreadful but what makes it more alarming is the fact that most of the killings that took place in the Philippines were perpetuated not by hardened criminals but by policemen who were expected to protect the welfare of the people. According to the administration, most of those killings occurred in order to protect the lives of the policemen whose lives were at stake during their encounters with criminals. These said killings call to reignite the discussion about what can be said as morally right or morally wrong through looking at the mere essence of morality in this society. Right and wrong is determined by the particular set of principles or rules the relevant culture just happens to hold at the time. Is something right (or wrong) because the gods command it, or do the gods command it because it is right? According to Rights-based Theories, We are to act in accordance with a set of moral rights, which we possess simply by being human. The right to life does not require that we give what is needed to sustain life rather merely that we refrain from taking any action that would take life.

A Doll s House By Henrik Ibsen - 1544 Words

Throughout the 18th and 19th centuries and even including all the way up to the 21st century, there has been questions generated on the gender roles of the society. Expectations can differentiate upon the behaviors and attitudes that affect men and women within those societies. In A Doll’s House, the gender roles match those that are consistent to the real world expectations of women’s rights. Henrik Ibsen, author of A Doll’s House, uses his play to represent the traditional gender roles of the time and even go further in depth to explain the reality of it all. Gender roles are supposed to be the way males and females should talk, think, dress, and how to go about everyday life. Between the 18th and 19th centuries, present day, and the†¦show more content†¦Women were not allowed to have much of a social life because of the responsibilities that were expected to take care of. Ibsen used the characters Torvald and Nora to emphasize the typical gender role norms. The â€Å"gender script† that society self-inflicted upon us, had been taken as a norm that people were consistently tried to correct. Nora Helmer is considered to be the stereotypical wife that was there for her husband, raised the children, and also followed the society’s view of gender roles. The husband of Nora was Torvald, who was the â€Å"man† of the house and was the dominant figure. As I read the book, I connected some ideas and information together that was a lot easier to understand the gender role side of the play. The connection I made was Nora being a doll in the doll house that represented herself in the real world. The reason for that connection was because she was forced to do whatever she was moved to do, just like playing with a doll house. You had no free range of motion and you were always in the owner’s control. That would have translated to the husband being the owner. The husband controlled the women like an owner controlled the dolls. Eventually, everyone needs to identify themselves and have some individualism. During the play, there were some similarities that compared the 18th and 19th century roles to the roles that Ibsen described. Towards the beginning of the play, the commonalities that were shown would have been the man controlling the female,